The Happy Hospitalist - Latest Comments in http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

Re: http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

Mehmet Karaca — Sat, 04 Jul 2009 04:41:14 -0000

This all started as when some studies suggested CRP is an indicator for high risk. Later researches started asking themselves whether the elevated CRP in CAD was simply indicator or the result of a parallel process. They have found, to nobody's surprise that many genotypes exist for CRP and people with some of these genotypes have higher CRP levels. They then tried to find an association between these variants and the risk of CAD which has failed as in this study and late last year in a similar study published in NEJM http://content.nejm.org/cgi.... If they were able to find an association with these genetic variants resulting in higher CRP levels and higher risk of heart disease, drug companies would likely try to develop molecules to suppress overproduction of CRP theorizing that this, in turn, would decrease cardiac risk.

Re: http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

Frank Drackman — Thu, 02 Jul 2009 09:34:35 -0000

Typical Internist...can talk for hours about a worthless test like C-R-P, but can't do C-P-R....
And JAMA's 50% Drug Ads...

Frank

Re: http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

countby5 — Thu, 02 Jul 2009 07:36:58 -0000

I think the Women's Health Study (2002?), Heart Protection Study 2(Zocor study), and the latest Jupiter (Crestor) study all address CRP as a factor in heart disease.

Re: http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

Frank Drackman — Wed, 01 Jul 2009 19:57:58 -0000

Whats CRP???

Re: http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

Anonymous — Wed, 01 Jul 2009 15:57:21 -0000

That's not what you title or entry suggest.

Re: http://thehappyhospitalist.blogspot.com/2009/07/does-elevated-crp-cause-heart-disease.html

Keith — Wed, 01 Jul 2009 14:07:04 -0000

Happy,

I think you missed the point of the article. CRP was thought to be a more poerful predictor of risk than LDL cholesterol. It did not necessarily state that it was the cause, but simply a marker for the presumed inflammation that occurs in the arteries of these patients. the more recent study suggests that CRP itself is not the protein causing the problem.